med's go on Instagram: "Liddle syndrome is an autosomal dominant disorder caused by a gain-of-function mutation in the epithelial sodium channel (ENaC), leading to excessive sodium reabsorption in the distal tubule, resulting in hypertension and hypokalemia. Due to sodium retention, renin and aldosterone levels are low (differentiating it from hyperaldosteronism, where aldosterone is high). Unlike Bartter and Gitelman syndromes, which present with normal or high renin and aldosterone, Liddle syn