The Buffalo Bills took on the Chicago Bears and lost in a 38-0 fashion in the second weekend of the 2025 NFL preseason. Sometimes the stats can tell the story of who performed well and who did not, but Pro Football Focus is there to provide a little bit more context.

The Bills take on the Bears in preseason game No. 2. Stay right here for live updates all afternoon and evening.

Caleb Williams took advantage of his first preseason playing time. He connected with Olamide Zaccheaus for a 36-yard touchdown on the opening drive as the Chicago Bears cruised to 38-0 preseason victory over the Buffalo Bills on Sunday night.

The Buffalo Bills are in win-now mode, and with Trey Hendrickson available, it might be time for Brandon Beane to get creative, says one NFL writer.

The Buffalo Bills suffered a brutal 38-0 beatdown at the hands of the Chicago Bears at Soldier Field on Sunday in their second preseason game. “Certainly not up to our standard, what we expect,” coach Sean McDermott said. “Got a lot of work to do. That’s very clear.”