New findings for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell–cell adhesion, growth factor signaling, and tumor suppression.

Treating FGFR-related cancers can involve using receptor tyrosine kinase inhibitors that bind to the hydrophobic pocket to block the receptor, which may effectively treat the cancer but also ...

Bender AT, Gardberg A, Pereira A, et al. Ability of Bruton’s tyrosine kinase inhibitors to sequester Y551 and prevent phosphorylation determines potency for inhibition of Fc receptor but not B ...

In a cell, there are tens of thousands of individual components. Each component has a specific activity that the cell needs to function and survive. Controlling this chaos is the role of signaling ...

Clearly this must have something to do with Bruton tyrosine kinase. Can you explain what BTKs are? Anthony R. Mato, MD, MSCE:Sure. BTK is an enzyme that’s part of the B-cell receptor signaling ...

Discovery of Bruton's tyrosine kinase (BTK) mutations as the cause for X-linked agammaglobulinemia was a milestone in understanding the genetic basis of primary immunodeficiencies. Since then, studies ...

Bruton's tyrosine kinase (BTK) was originally identified in 1993 as a non-receptor protein tyrosine kinase that is defective in the inherited immunodeficiency disease X-linked agammaglobulinaemia ...