In general, SIRT3 inhibits the occurrence of FMT by regulating the acetylation levels of proteins such as GSK3β, Smad3, SOD2, and IDH2, while SIRT6 inhibits TGF-β1-induced related signal pathways by ...

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China The Hippo/YAP pathway is a signaling pathway that plays an ...

Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...