SUO 2024, urothelial carcinoma, FGFR and precision in urothelial carcinoma, Precision in Urothelial Carcinoma, downstream signaling through MAPK and PI3K/Akt pathways, FGFR inhibition in cancer, ...

A new study explores the potential of fibroblast growth factor receptor (FGFR) antagonists in restoring defective mandibular bone repair in mouse models of osteochondrodysplasia, a group of ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for developing effective treatments.

Conclusion: The data suggest that activated FGFR signaling accelerates autocrine loop of FGF production and FGFR-mediated activation of Akt signaling plays an important role in mature ...

AI, aromatase inhibitor; AKT, protein kinase B; CDK, cyclin-dependent kinase; CoA, coactivator; CoR, coactivator receptor; E2, estradiol; EGFR, epidermal growth factor receptor; ER, estrogen receptor; ...

CHICAGO -- Patients with FGFR -mutated advanced urothelial cancer that progressed after anti-PD-1/L1 therapy lived significantly longer if they received the selective FGFR inhibitor erdafitinib ...

There are currently 3 FDA-approved therapies to treat cholangiocarcinoma with FGFR2 fusion or rearrangement, but these therapies face the development of resistance. Studies are underway to ...

We observed only a slight increase in AKT phosphorylation, as even in untreated cells the level of phosphorylated AKT was relatively high. As expected, in HCC15 (FGFR-negative) cells, only EGF ...

In the FIGHT-101 study, clinical activity was demonstrated with pemigatinib in patients with FGF/FGFR-altered tumors.

Small-molecule FGFR inhibitors have been reviewed by others in the past several years, but these papers mainly focused on small molecules targeting the kinase domain. Herein, we make a systematic and ...

Drugs targeting FGFR mutations, which are seen in patients with intrahepatic cholangiocarcinoma (CCA), have generated particular excitement; the authors note that prior to the approval of ...

Intriguingly, when the MEK pathway was blocked, Akt was robustly activated and could rescue FGF1-driven glucose uptake, showing that there is considerable flexibility within the FGF1/FGFR signaling ...