Aging is a significant risk factor for male fertility and can lead to severe developmental disorders in offspring. It disrupts testicular function and spermatogenesis, resulting in sperm abnormalities ...

HUTCHMED has announced the completion of patient enrollment in a Phase II trial for fanregratinib (HMPL-453), aimed at treating intrahepatic cholangiocarcinoma (IHCC) patients with FGFR2 fusion ...

They discovered that activation of FGFR2 led to excessively high bone ... and the upregulation of genes involved in apoptosis and the MAPK signaling pathway (like Dusp3 and Socs3).

This fundamental article significantly advances our understanding of FGF signalling, and in particular, highlights the complex modifications affecting this pathway. The evidence for the authors' ...

MEG3 promotes cell apoptosis through the MEG3/miR-195-5p/FGFR2 signaling axis. MEG3 can regulate miR-21, target Caspase-8 to regulate cell proliferation and apoptosis, and inactivate the PI3K/Akt ...

We observed that FGF10 efficiently reduced I/R-induced elevation in blood urea nitrogen, serum creatinine as well as apoptosis induction of RTCs. Interestingly, autophagy activation following I/R was ...