TRPV1 expression regulation… A further step in defining its biology: commentary for K. Zavala et al. "The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion ...

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of ...

Cladribine can help people with the active relapsing-remitting version of the disease, as well as more severe, highly active MS, for which it is already used, says drug advisory body NICE.

Across all comparisons (fingolimod, DMF, and teriflunomide), cladribine was associated with significantly lower relapse rates and higher treatment persistence. Compared with fingolimod ...

A carpal boss is often mistakenly misdiagnosed as a ganglion cyst because of the similarity in appearance and location. Unlike a ganglion cyst, a carpal boss is not movable under the skin. Bone spurs ...

Trigeminal neuralgia is an uncommon facial pain syndrome affecting a nerve in the head called the trigeminal nerve. It causes repeated episodes of sudden, extreme, pain like an electric shock on the ...

Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen. HSV-1 genomes persist in trigeminal ganglia neuronal nuclei as chromatinized episomes, while epithelial cells are typically killed by ...

At year 4, in patients with relapsing MS treated with cladribine, correlation was observed between the BICAMS components and the MSQoL-54 scores, which suggests a relationship between better ...

Retinal ganglion cells (RGCs) are the bridging neurons that connect the retinal input to the visual processing centres within the central nervous system. There is a remarkable diversity of RGCs and ...

The striatum and the subthalamic nucleus (STN) constitute the input stage of the basal ganglia (BG) network and together innervate BG downstream structures using GABA and glutamate, respectively.