Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

BRCA1/2 mutation carriers exhibited a more pronounced pathologic complete response rate, especially with carboplatin. The study predates the immunotherapy era, necessitating contextual interpretation ...

Many mutations, such as those found in the well-known BRCA1 and BRCA2 genes, are passed down in what’s called an autosomal dominant pattern. This means that inheriting one bad gene from one ...

A comparison of patients with and without BRCA gene mutations receiving prophylactic risk-reduction surgery suggest ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...

Mutations in BRCA1 and BRCA2 -- tumor suppressor genes that play a crucial role in DNA repair -- substantially increase the likelihood of cancer. These cancers are, however, quite sensitive to ...

Genetic and genomic testing guide breast cancer risk assessment and treatment, as discussed by Dr. Mark Robson at the Miami ...

Can a "mastectomy moon" help prepare you for surgery? A cancer survivor explains how a pre-surgery trip helped her find peace ...

This surge reflects the increasing reliance on genetic diagnostics for identifying hereditary diseases, guiding cancer ...