Expression of PlGF splice variants was not correlated with clinical variables. Interestingly, expression levels of VEGFR-1 predict presence of DTCs in bone marrow (p = 0.002). Patients with DTC in ...

VEGFR-1 also serves as a receptor for both PlGF and VEGF-B (ref. 12). Experiments on VEGFR-1 have provided tantalizing data, but have revealed little about its function in adult mice.

In order to wisely skirt this catastrophic event, Lois E. H. Smith and colleagues utilized placental growth factor-1 (PlGF-1), which exclusively activates the VEGF receptor-1 (VEGFR-1).

More information: J. Incio et al. PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity, Clinical Cancer Research (2016).

In order to wisely skirt this catastrophic event, Lois E. H. Smith and colleagues utilized placental growth factor-1 (PlGF-1), which exclusively activates the VEGF receptor-1 (VEGFR-1).

1. Incio J, Tam J, Rahbari NN, et al. PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity [published online February 9, 2016].

Among 127,710 patients with various cancer types, 37,308 patients were treated with VEGFR-TKIs (sorafenib, regorafenib, vandetanib, sunitinib, lenvatinib, axitinib, or pazopanib), whereas 90,402 ...

Their findings in cellular and animal models, as well as in patient tumor samples, indicate that targeting the PlGF/ VEGFR-1 pathway may be particularly effective in obese patients.

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PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity. Clinical Cancer Research, 2016; DOI: 10.1158/1078-0432.CCR-15-1839 ...