Zanzalintinib plus Tecentriq significantly improved overall survival versus Stivarga in previously treated metastatic ...

Multiple sclerosis (MS) includes both peripheral and central nervous system (CNS) inflammation, and an anti-inflammatory small molecule therapy that can cross the blood-brain barrier may be attractive ...

New findings for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell–cell adhesion, growth factor signaling, and tumor suppression.

Treating FGFR-related cancers can involve using receptor tyrosine kinase inhibitors that bind to the hydrophobic pocket to block the receptor, which may effectively treat the cancer but also ...

Covalent (irreversible) Bruton’s tyrosine kinase (BTK) inhibitors bind to the C481 residue of BTK and block the ATP-binding pocket, thereby preventing catalytic activity.

ERK and Akt are tyrosine kinases responsible for signaling pathways involved in cellular proliferation, while MMP9 is linked to cell adhesion. ERK and Akt are often abnormally activated in cancer, so ...

Clearly this must have something to do with Bruton tyrosine kinase. Can you explain what BTKs are? Anthony R. Mato, MD, MSCE: Sure. BTK is an enzyme that’s part of the B-cell receptor signaling ...

Discovery of Bruton's tyrosine kinase (BTK) mutations as the cause for X-linked agammaglobulinemia was a milestone in understanding the genetic basis of primary immunodeficiencies. Since then, studies ...