American oncology company Oncternal Therapeutics is to wind down operations after announcing the sale of its main drug ...

Zanzalintinib plus Tecentriq significantly improved overall survival versus Stivarga in previously treated metastatic ...

These mechanisms are linked ... rich repeat kinase 2) promote α-syn phosphorylation and impair autophagy. Oxidative stress is worsened by MAO-B (monoamine oxidase B), which produces toxic byproducts ...

The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth factor receptors that when activated induce mitogenic, motogenic, and morphogenic cellular responses. The ...

Blossomhill Therapeutics Inc. has synthesized new indazole-based macrocyclic compounds acting as ALK tyrosine kinase receptor inhibitors potentially useful for the treatment of cancer.

John Mascarenhas, MD, discusses the rationale, mechanism, and design of the phase 1 INCA33989-101 and -102 trials investigating a CAL-R–targeted antibody for patients with essential thrombocythemia.

Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.

Cannabidiol (CBD) is one of several cannabinoids found in the Cannabis sativa plant that may help treat anxiety. Here, we look at the best CBD products for anxiety.

Small-molecule irreversible tyrosine kinase inhibitors as high potent agents have led to improvements in disease-free and overall survival in patients with HER2-amplified cancer. The approved ...