BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...

Leucine-rich repeat-containing 8A (LRRC8A) is a ubiquitously expressed transmembrane protein that functions as the essential ...

Giant migrating contractions (GMCs) are powerful waves of colonic movement that propel intestinal contents toward the anus ...

Innate immunity is a cornerstone of the body’s immediate defense against cancer, orchestrating the early recognition and response to tumor cells through key ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Gut microbiome changes may drive age-related memory loss via inflammation and disrupted brain signaling, but interventions in mice show this process can be reversed.

Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which healthy lung tissue is gradually replaced by scar tissue. While the early events that initiate this change are poorly understood, ...

A research team has uncovered how key polyphenols from dandelion help suppress inflammation by regulating the AGE–RAGE signaling pathway, a biological route strongly linked to chronic inflammatory ...