Phase II Study of Erdafitinib in Tumors with FGFR Amplifications and Mutations or Fusions JCO Precision Oncology Conversations 0:00 28:47 1xMay 15, 2024 Transcript Dr. Rafeh Naqash: Hello and welcome ...

Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect ...

Historically, FGFR inhibitors have failed to demonstrate significant response rates in tumors harboring FGFR1-3 mutations, with the exception of FGFR2 extracellular in-frame deletions. 6 Additional ...

This mutation causes cancers to grow rapidly and spread. The new trial will focus on patients with pancreatic cancer, about 1% of whom harbor FGFR mutations.

A new study explores the potential of fibroblast growth factor receptor (FGFR) antagonists in restoring defective mandibular bone repair in mouse models of osteochondrodysplasia, a group of ...

The Ohio State University researchers are also hoping to enroll patients for a trial that is specific to pancreatic cancer patients with the FGFR gene mutation.

FGFR mutation or overamplification has been shown to cause breast, lung, endometrial, and gastric cancers, as well as hepatocellular carcinoma.

The Ohio State researchers are also hoping to enroll patients for a trial that is specific to pancreatic cancer patients with the FGFR gene mutation.

Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect ...