It is unclear why FGFR inhibitor has some activities toward t cells since ... the cell biopsies only show reduced phosphorylation of ERK, but not AKT. This is at odds with the ex vivo cell-based ...

potentially influencing cell survival and apoptosis through FGFR-mediated pathways[4]. Lastly, studies on the inhibition of the Akt/PKB kinase have shown that this process can enhance the activity ...

The following antibodies were used: from Cell Signaling Technology, phospho-FGFR Tyr653/654 (Cell Signaling Technology ... 1:1000), phospho-p38 Thr180/Tyr182 (4511T, 1:1000), AKT (9272S, 1:1000), ...

Pediatric low-grade gliomas represent the most common childhood brain tumor class. While often curable, some tumors fail to respond and even successful treatments can have life-long side effects. Many ...

The Phase II eNRGy trial showed durable antitumor activity with zenocutuzumab (Bizengri) in patients with NRG1 ...

UTRECHT, The Netherlands and CAMBRIDGE, Mass., Feb. 05, 2025 (GLOBE NEWSWIRE) -- Merus N.V. (Nasdaq: MRUS) (Merus, the Company, we, or our), a ...

Compound 10 demonstrated broader potency against FGFR2/3 mutants acquired after the approved FGFR drug treatments. It also exhibited robust selectivity, sparing FGFR1/4, and showed minimal off ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

The next chapter of AI’s ongoing evolution will center on the interconnectivity technologies of high-performance processors. Arista Networks’ solutions are increasingly seen as the industry ...

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