Morice, A., et al. (2025). FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia. Bone Research. doi.org/10.1038/s41413-024-00385-x.

A new study explores the potential of fibroblast growth factor receptor (FGFR) antagonists in restoring defective mandibular bone repair in mouse models of osteochondrodysplasia, a group of ...

The study calls for further clinical trials to test FGFR and NOTCH inhibitors in ETMR patients and explores antisense therapies targeting C19MC miRNAs, which have shown promise in lab settings.

Drugs targeting FGFR mutations, which are seen in patients with intrahepatic cholangiocarcinoma (CCA), have generated particular excitement; the authors note that prior to the approval of ...

In their review, the authors describe the FGFR pathway, its role in oncogenesis, current FGFR inhibitors, the role these inhibitors play in treatment cholangiocarcinoma, and the future of the field.

Correspondence Targeted FGFR Blockade for the Treatment of Tumor-Induced Osteomalacia Published September 9, 2020 N Engl J Med 2020;383: 1387 - 1389 DOI: 10.1056/NEJMc2020399 ...

We identified 41 patients with tumors harboring an oncogenic FGFR alteration. Median age at diagnosis was 8 years (range, 6 months-26 years). Diagnoses included 11 rhabdomyosarcomas, nine low-grade ...

Futibatinib demonstrated clinical benefit among previously treated patients with fibroblast growth factor receptor 2 fusion- or rearrangement-positive intrahepatic cholangiocarcinoma, according to ...

Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect ...