The research delves into how mutations in FGFR2 and FGFR3 affect mandibular ... only promoted chondrocyte differentiation and increased apoptosis rates in the population of hypertrophic ...

They discovered that activation of FGFR2 led to excessively high bone ... and the upregulation of genes involved in apoptosis and the MAPK signaling pathway (like Dusp3 and Socs3).

HUTCHMED has announced the completion of patient enrollment in a Phase II trial for fanregratinib (HMPL-453), aimed at treating intrahepatic cholangiocarcinoma (IHCC) patients with FGFR2 fusion ...

This fundamental article significantly advances our understanding of FGF signalling, and in particular, highlights the complex modifications affecting this pathway. The evidence for the authors' ...

NEW YORK – Hutchmed on Thursday said it has completed enrollment of a Phase II trial in China testing the FGFR1/2/3 inhibitor fanregratinib in patients with advanced intrahepatic cholangiocarcinoma ...

Department of Dermatology of the Affiliated Hospital of Guiyang Medical University. Apoptosis is involved in aging and age-related disease, with respect to aging, apoptosis acting in a ...

In this important study, Li and others identified cell membrane receptors for juvenile hormone (JH), a terpenoid hormone in insects that regulates their development and reproduction. While ...

Aging is a significant risk factor for male fertility and can lead to severe developmental disorders in offspring. It disrupts testicular function and spermatogenesis, resulting in sperm abnormalities ...

While until recently apoptosis was discussed as being essential for epithelial turnover and tissue homeostasis in the intestinal epithelium, recent data using gene deficient mice have challenged this ...

1 Department of Breast Surgery, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China 2 Department of Breast Surgery, The First Affiliated Hospital of Hainan ...