More information: FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development, Cancer Research (2025). DOI: 10.1158/0008-5472.CAN-24-4576 ...

Precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein, and FGFR2 inactivation ...

Notably, FGFR2 expression in murine precancerous lesions correlated with an increase in mutant KRAS signaling. "We know that precancerous pancreatic lesions often carry KRAS mutations," said Tonelli.

She and her colleagues recently discovered that KRAS gets mutated from another gene called FGFR2, making “those ‘early versions’ of pancreatic cancer become much more aggressive.” The gene ...

In February 2025, Insilico published a research paper in the Journal of Medicinal Chemistry entitled "Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 ...

By inhibiting the cancer gene FGFR2, they were able to slow tumor formation. By targeting the FGFR2 and EGFR proteins, they were able to prevent pancreatic cancer from forming in the first place.