EurekAlert!5d
New understanding of B cell mutation strategies could have implications for vaccines
New study demonstrates how high-affinity B cells "bank" their best traits instead of rolling the dice and risking deleterious mutations, with implications for better vaccine design.
Nature20d
GJB2 and GJB6 Mutations in Children with Congenital Cytomegalovirus Infection
Whether connexin mutations are factors in the development of CMV-related hearing loss has not been explored. We examined gap junction protein beta-2 (GJB2) and gap junction protein beta-6 (GJB6 ...
BioWorld26d
Enanta Pharmaceuticals discloses c-KIT inhibitors
Enanta Pharmaceuticals Inc. has developed mast/stem cell growth factor receptor kit (KIT; c-KIT; CD117) inhibitors reported to be useful for the treatment of cancer, autoimmune disease, fibrosis, ...
Frontiers2y
An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors
PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; PKC, protein kinase C; PI3K ... of action maintains KIT and PDGFRA in an inactive conformation independent of the ...
Frontiers2y
Rare KCND3 Loss-of-Function Mutation Associated With the SCA19/22
A BCA Protein Assay Kit (KeyGEN, Cat. #KGP902 ... In our study, the c.1130 C>T (p.T377M) mutation of the KCND3 gene was reported in the Chinese mainland family for the first time. To further explore ...