The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption ...
Scientists are aiming to determine the composition and topology of physiological Ashwell-Morell receptor ligands. Their findings will help uncover the receptor's still-hidden secrets. After earning ...
G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...
We have known for a while that being high is the result of what occurs in a single cellular structure known as cannabinoid receptor 1 (CB1), and we know that our bodies produce their own ...
What we can learn from fish calcitonin and its receptor: Evolutionary insights and medical potential
In fish, multiple HBD of CTR and stable ɑ-helix of calcitonin contribute to the high binding affinity and slow dissociation, thus triggering prolonged AC/cAMP signaling. In humans, RAMP dependent ...
In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights ...
Activation of the serotonin receptor, 5-HT1A, has been shown to regulate mood and cognition. The receptor is the primary target of buspirone, vilazodone, and gepirone, FDA-approved medications for the ...
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