We're getting our first Thursday night game of December, and things are starting off with a bang with the Lions hosting the Cowboys in an NFC showdown. This is the old "Thanksgiving leftovers" game where the NFL takes two teams that played on Thanksgiving and has them play each other the following Thursday.

Meanwhile, Joe Burrow and the Bengals could play spoiler against the Bills, and we're not buying the Bears quite yet.

Get the best Cowboys vs. Lions, predictions, expert NFL picks, and odds for Thursday Night Football on December 4, 2025. Take the Over.

See who's in and who's out for the Week 14 matchup between the Los Angeles Rams and Arizona Cardinals on December 7, 2025.

The Lions already became the first NFL team to clinch a playoff spot in Week 14, and they could be followed by the Eagles and Vikings on Sunday.

Thanks to a surprising Los Angeles Rams loss in Week 13, the Seattle Seahawks once again have a pathway to winning their division, albeit a small one.

The Week 14 NFL schedule is loaded with games that have playoff implications. Here are bold predictions for four of the most important matchups.