Background. Oritavancin is a lipoglycopeptide antibiotic with rapid bactericidal activity against gram-positive bacteria. Its concentration-dependent activity and long half-life allow for single-dose ...

Nature Chemical Biology paper suggests that bacteria detect the antibiotic itself and not its effect on the bacterial cell wall. Researchers report that they have figured out how bacteria recognize ...

Recently, a research team led by Prof. SUN Baolin from the University of Science and Technology of China (USTC) revealed the mechanism of transcriptional regulation via S-nitrosylation for vancomycin ...

Vancomycin flushing syndrome (VFS) is a reaction to the antibiotic drug vancomycin. Common symptoms consist of a rash that itches during or after the infusion of vancomycin. VFS is the most common ...

Translocation of lipid II across the cytoplasmic membrane is essential in peptidoglycan biogenesis. Although most steps are understood, identifying the lipid II flippase has yielded conflicting ...