scientific understanding of the anti-TIGIT pathway and new avenues in cancer research.” Roche has another half-dozen phase 3 trials on the go with tiragolumab in other NSCLC settings ...

and supports the potential therapeutic benefit of inhibiting the TIGIT pathway.” “I was also encouraged by the consistency of meaningful improvements across other outcome measures for the ...

While the broader immuno-oncology space has been dominated by PD-1 and TIGIT inhibitors, Compugen is targeting the under-explored PVRIG pathway with their lead asset COM701. The industry has seen ...

The company identified PVRIG and TIGIT as immune checkpoints in the DNAM axis, an important signaling pathway in T- and NK-cell function, which led to the discovery and development of novel ...

[miR-18a ameliorates inflammation and tissue injury in a mouse model of allergic rhinitis via blocking TLR4/NF-κB pathway]. [The number of TIGIT+CD8+ T cells increases but their cytokine ...