Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an ...
Illuminating the immune response to aberrant DNA
Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...
Nanowerk3y
cGAS–STING cytosolic DNA sensing pathway
The cGAS–STING pathway is a component of the innate immune system that ... Upon recognition of a PAMP, PRRs generate signal cascades leading to transcription of genes associated with the immune ...
EurekAlert!10mon
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). (IMAGE)
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...
News Medical on MSN7d
A chance to fight both cancer and inflammation and a prospect for dementia diagnostics
In recognition of their discovery of one of our immune system’s foundations, physician Andrea Ablasser, virologist Glen Barber and biochemist Zhijian ...
Medscape1mon
IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity.
This research aims to explore the relationship between IL-33/ST2 and stimulator of interferon (IFN) response cGAMP interactor 1 (STING)-mediated signal transduction. METHODS: C57BL/6N mice (WT ...