A phase 1, multicenter, open-label study of marizomib (MRZ) with temozolomide (TMZ) and radiotherapy (RT) in newly diagnosed WHO grade IV malignant glioma (glioblastoma, ndGBM): Dose-escalation ...

The choroid plexus (ChP) is an epithelial tissue within the brain ventricles responsible for the production of cerebrospinal fluid (CSF). CSF is essential for brain functions, and it interconnects the ...

Scientists have discovered microglia actually squeeze through the spinal boundary, crossing into the peripheral nervous system in response to injury. Inside the body, disease and injury can leave ...

The central nervous system (CNS) is especially sensitive to inflammation. Encased within the rigid boundaries of the skull and vertebral column, oedema resulting from inflammation causes dangerous ...

Glioblastoma response to blood-brain-barrier permeable, MGMT-agnostic therapeutic LP-184 and sensitization by nucleotide-excision repair deficiency. This is an ASCO Meeting Abstract from the 2022 ASCO ...