In a paper published in the journal Neuron, researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic ...

Pain is a complex, multifaceted experience shaped by various factors beyond physical sensation, such as a person's mindset and their expectations of pain. The placebo effect, the tendency for a person ...

A review of 22 clinical studies published in JAPI found that topical capsaicin 0.075% reduced pain by up to 65% ...

Correspondence to Dr Mikkel Bek Clausen, Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, Faculty of Health, University College Copenhagen, Copenhagen, Denmark; ...

Nearly everyone is familiar with the feeling of accidentally touching a hot vessel or holding onto something freezing for too long. Normally, pain serves to protect from potential harm, but when the ...

An international research group led by MedUni Vienna and IMBA—Institute of Molecular Biotechnology, Vienna, has made significant progress in understanding the mechanisms that influence the sensation ...

Neuropathic pain - abnormal hypersensitivity to stimuli - is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from ...

Over half of the people carrying HIV experience chronic pain at some point, which is difficult to treat. In a new JNeurosci ...

Three floors below Dmitriy Sheyn’s lab at Cedars-Sinai Medical Center, doctors remove degenerated intervertebral discs from patients with severe back pain. Instead of tossing the old discs, however, ...

Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer ...