However Sunday night, the 272nd and final game of the regular season, will have winner-take-all stakes as the archrival Pittsburgh Steelers and Baltimore Ravens vie for the AFC North title in the latest installment of their border way. The loser goes gets nothing.

Overall picks to win: 8-8 in Week 17 (173-82-1 for the season) Picks to win with 1-5 confidence: 4-7 (103-64-1) Picks to win with 6-10 confidence: 4-1 (70-18) Overall to cover the spread: 9-6-1 (130-117-9) Cover-the-spread picks with 1-5 confidence: 8-4-1 (107-93-8) Cover-the-spread picks with 6-10 confidence: 1-2 (23-23-1)

The Tampa Bay Buccaneers are coming off losses in seven of their last eight games, and yet they still can win their division in 2025. However, they do need to defeat the Panthers in Week 18 and rely on the Saints to defeat the Falcons.

Week 18 will kick off Saturday afternoon from Tampa where the Buccaneers (7-9) and Carolina Panthers (8-8) will square off with the NFC South division title and the conference's No. 4 postseason seed on the line.