For decades, scientists have fought cancer by developing small molecules to inhibit kinase enzymes. These enzymes play an important role in a host of cellular processes, including phosphorylation and ...

When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among ...

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where kinases – ...

Molecular dynamics simulations have emerged as an indispensable tool in modern biomedical research, particularly in the study of protein kinases. This computational approach permits detailed ...

DeepTarget is a computational tool that integrates large-scale drug screens with omics data to predict mechanisms of cancer cell killing.

Phase I/II Trial Evaluating the Anti-Vascular Endothelial Growth Factor Monoclonal Antibody Bevacizumab in Combination With the HER-1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ...

A new study led by Professor Kui Liu at the University of Gothenburg has identified the key molecule 'Greatwall kinase' which protects women's eggs against problems that can arise during the ...

Phase Ib study evaluating the combination of BIBW 2992 with two different standard chemotherapy regimens, cisplatin/paclitaxel (PT) and cisplatin/5-FU (PF), in patients with advanced solid tumors. Fc ...

Busy Iambic Therapeutics has picked up more than $100 million in new funding as it looks to advance its portfolio of ...