AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
ascopubs.org

MCT1-mediated histone lactylation modulates lung cancer cell sensitivity to T-cell–mediated killing by influencing mitochondrial dysfunction.

Comparison of induction chemoimmunotherapy with surgery and concurrent chemoradiation followed by immunotherapy for potentially resectable stage III non-small-cell lung cancer: A retrospective study.
ascopubs.org

Machine learning–driven approaches for predicting T-cell–mediated immunity and beyond.

Effect of KROS 101, a small molecule GITR ligand agonist, on T effector cells, T reg cells and intratumoral CD8 T cell cytotoxicity. Phase 1 study of DK210 (EGFR), a tumor-targeted IL2 x IL10 dual ...