All positive (IHC 3+) and doubtful (IHC 2+) cases were screened by fl uorescence in situ hybridization (FISH). Patients with HER2 gene amplification, normal left ventricular ejection fraction ...

A FISH test uses specialized fluorescent dye and DNA to show changes in chromosomes and can also show levels of the HER2 gene. Treating triple-positive breast cancer may include using a ...

2+ (Score of 2): There’s an intermediate level of HER2 protein. This score is borderline, and further testing, usually with FISH, is recommended to clarify HER2 status. 3+ (Score of 3): There ...

Too many copies of the HER2 gene or its overexpression appeared to cause an especially aggressive form of the disease. By the late ’90s, a drug called Herceptin that targeted the HER2 receptor, sped ...