FGFR amplification. Amplification of FGFR1 (8q12 locus) is found in approximately 17% of squamous non-small-cell lung carcinoma (NSCLC) cases 9,10 and approximately 6% of small-cell lung carcinoma ...

Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398. Molecular Cancer Therapeutics , 2017; DOI: 10.1158/1535-7163.MCT-15-1010 Cite This Page : ...

Aggarwal C, Redman MW, Lara PN Jr, et al: SWOG S1400D (NCT02965378), a phase II study of the fibroblast growth factor receptor inhibitor AZD4547 in previously treated patients with fibroblast growth ...

FGFR mutation or overamplification has been shown to ... there is some research suggesting that combination therapy with treatment that inhibits the PI3K/AKT/mTOR pathways may overcome this ...

Co-lead author of the study, Dr. Volker Hovestadt, explained, "We discovered that FGFR and NOTCH receptors are expressed by proliferative NSC-like cells, while more differentiated malignant cells ...

Futibatinib demonstrated clinical benefit among previously treated patients with fibroblast growth factor receptor 2 fusion- or rearrangement-positive intrahepatic cholangiocarcinoma, according to ...

FGFR Drug Market To Surpass USD 4 Billion By 2026 Says Kuick Research. Delhi, Nov. 18, 2021 (GLOBE NEWSWIRE) -- Global Fibroblast Growth Factor Receptor Inhibitor Drug Market Opportunity and ...

A new study explores the potential of fibroblast growth factor receptor (FGFR) antagonists in restoring defective mandibular bone repair in mouse models of osteochondrodysplasia, a group of ...

Examining other molecules in the FGFR pathway, the researchers found that a regulatory protein called Akt remained highly active, even during FGFR inhibition. Akt, a key regulator of cell biology ...

A new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has identified a ...