The research delves into how mutations in FGFR2 and FGFR3 affect mandibular ... only promoted chondrocyte differentiation and increased apoptosis rates in the population of hypertrophic ...

These treatments not only promoted chondrocyte differentiation and increased apoptosis rates in the population of hypertrophic chondrocytes of the calluses, but also enhanced bone formation and ...

However, developing highly selective FGFR2/3 inhibitors and overcoming drug resistance remain two of the most significant challenges in the field. Recently, Insilico Medicine ("Insilico ...

They discovered that activation of FGFR2 led to excessively high bone mineralization ... and the upregulation of genes involved in apoptosis and the MAPK signaling pathway (like Dusp3 and Socs3). The ...